Clostridium difficile colitis that fails conventional metronidazole therapy: response to nitazoxanide
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منابع مشابه
Clostridium difficile colitis that fails conventional metronidazole therapy: response to nitazoxanide.
OBJECTIVES Clostridium difficile-associated disease has increased in incidence and severity. Recommended treatments include metronidazole and vancomycin. Recent investigations, however, document the failure of metronidazole to cure a substantial proportion of patients with Clostridium difficile colitis, but oral administration of vancomycin raises concerns over selection of antibiotic-resistant...
متن کاملNitazoxanide versus metronidazole for Clostridium difficile-associated colitis.
To the Editor—Reports of increased incidence and severity of Clostridium difficile–associated colitis have stimulated interest in the search for additional treatment options for this clinical problem. Musher et al. [1] recently reported the results of a noninferiority study that compared metronidazole with nitazoxanide for the treatment of C. difficile colitis. The authors concluded that “nitaz...
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Bacteriology and Pathogenesis Clostridium difficile is a Gram-positive sporeforming anaerobic bacillus, which is found in the stool flora of 25-80% of healthy infants but rarely in the stool of healthy adults and children over the age of 12 months. Ingested spores of C. difficile survive the gastric acid barrier and germinate in the colon. Colonization of the adult intestinal tract occurs when ...
متن کاملClostridium difficile-associated colitis.
OBJECTIVE To review the basic microbiology, pathogenesis of disease, and diagnosis of the nosocomial pathogen Clostridium difficile and to examine therapies recommended by the Canadian Task Force on Preventive Health Care. QUALITY OF EVIDENCE MEDLINE: was searched using MeSH headings. Controlled trials for therapy were sought, but case-control studies and observational reviews were included. ...
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In recent years, the incidence and severity of Clostridium difficile-associated disease (CDAD) have increased dramatically. Beginning in 2000, widespread regional outbreaks associated with a previously uncommon hypervirulent strain of C. difficile have occurred in North America and Europe. Most likely because of increased toxin production as well as other virulence factors, this epidemic strain...
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ژورنال
عنوان ژورنال: Journal of Antimicrobial Chemotherapy
سال: 2007
ISSN: 1460-2091,0305-7453
DOI: 10.1093/jac/dkl553